• our science our science Our Science

    • By Industry

      • Bioprocessing

        • Upstream

        • Downstream

        • Fill/Finish

        • Oligonucleotides

      • Cell and Gene Therapy

        • Upstream

        • Downstream

        • Fill/Finish

        • Oligonucleotides

      • Pharmaceutical

        • Oligonucleotides

        • Small Molecule

    • By Application

      • Buffer Prep

        • Chemical and Bioprocessing Containers

        • Filtration and Purification

        • Mixing Systems

        • Tubing and Pipe

        • Tube Sets and Manifolds

        • 2D and 3D Bags

        • Cynergy® Fittings

        • Cynergy® Valves

        • Custom Dip Tubes, Tanks, and Containers

        • NOWPak® Liner Based Systems

      • Bulk Fill

        • 2D and 3D Bags

        • Tube Sets and Manifolds

      • Cell Growth

        • Motion Bioreactor Bags

        • 2D and 3D Bags

        • Tubing and Pipe

        • Tube Sets and Manifolds

      • Cell Separation

        • Filtration and Purification

        • Tube Sets and Manifolds

        • Tubing and Pipe

        • 2D and 3D Bags

        • Microcarrier and Cell Separation Systems

      • Facilities/Bulk Chemicals

        • Chemical and Bioprocessing Containers

        • 2D and 3D Bags

        • NOWPak® Liner Based Systems

        • Tube Sets and Manifolds

      • Fill/Finish

        • Tube Sets and Manifolds

        • 2D and 3D Bags

      • Freezing

      • Media Prep

        • 2D and 3D Bags

        • Filtration and Purification

        • Mixing Systems

        • Tube Sets and Manifolds

        • Tubing and Pipe

      • Medical Devices

        • Dental

        • Eye Care

        • Implantable Devices

        • Medical Ultrasound

        • Wound Care

      • Quality Control

        • Particle Characterization

      • RNA and DNA Solutions

        • Oligonucleotides

      • Small Molecule

        • Liquid Filters

        • Catalysts

        • Ligands

        • Organophosphorus Compounds

        • Filtration and Purification

      • Storage

        • Chemical and Bioprocessing Containers

        • 2D and 3D Bags

        • Tubing and Pipe

        • Tube Sets and Manifolds

        • NOWPak® Liner Based Systems

    • By Location

      • Hangzhou Facility

      • Life Sciences Technology Center

  • product catalog product catalog Product Catalog

    • Single-Use Assemblies

      • 2D and 3D Bags

      • Mixing Systems

      • Motion Bioreactor Bags

      • Microcarrier and Cell Separation Systems

      • Tube Sets and Manifolds

    • Filtration and Purification

      • Liquid Filters

      • Vent Gas Filters

    • Fluid Management

      • Tube Sets and Manifolds

      • Cynergy® Valves

      • Cynergy® Fittings

      • Custom Dip Tubes, Tanks, and Containers

      • Tubing and Pipe

    • Process Monitoring

      • Particle Characterization

    • Chemical Packaging

      • FluoroPure® HDPE Blowmolded Drums

        • FluoroPure® Trilayer HDPE Blowmolded Drums

        • FluoroPure® Advantage Trilayer HDPE Blowmolded Drums

      • NOWPak® Liner-Based Systems

      • FluoroPure® Composite Drums

      • FluoroPure® Intermediate Bulk Containers

      • Sentry® Quick Connect Systems

    • Specialty Chemicals

      • Catalysts

      • Ligands

      • Organophosphorus Compounds

      • Siloxanes

      • Specialty Acrylates and Methacrylates

      • Specialty Additives

    • Premium Graphite

      • Life Sciences Graphite Grades

      • Premium Graphite Components

      • Graphite Processing Options

  • resources resources Resources

    • Industry Insights

      • Aramus™ Shaped 2D Single-Use Bags

      • Cell and Gene Therapy

      • Cold Chain Bioprocessing

      • Filter Bag Assembly

      • High-Density Cell Banking

      • Life Sciences Filtration

      • Low-Temperature Bioprocessing

      • Nanoparticles

      • Pandemic Response

      • Particle Characterization

      • Single-Use Solutions for Bioprocessing

      • USP Subvisible Particulate Testing

    • Reference Materials

    • Technical Information

      • Chemical Compatibility

      • Material Properties and Safety

      • Particle Characterization Applications

    • Entegris Blog

  • about us about us About Us

    • Corporate Overview

    • Corporate Social Responsibility

    • Careers

    • Events

    • Investor Relations

    • Legal/Trademark Notices

    • Locations

    • News Releases

    • Media Coverage

    • Entegris Blog

Our Sites Our Sites Our Sites
more more More

Bulk Fill

Products to fit your operation and protect end-stage bulk drug products while significantly reducing cost and risk.

The bulk filling stage of the downstream bioprocess involves significant resource investment in production, purification, and concentration. As a late-stage process, it can have a potential safety impact to the end user, who could be an already compromised patient. After a drug is bulk filled in a cleanroom, there are few safeguards to ensure its sterility. Partnering with us, we can make products to fit your operation and protect end-stage bulk drug products while significantly reducing cost and risk.  

We offer a variety of single-use products for the bulk fill process including bag assemblies, mixing systems, and custom tube sets and manifolds. We can configure them to fit your application requirements, providing closed system solutions for the last stages of your bioprocess. We partner with you in the design and configuration of bulk fill solutions and provide expertise to assure supply, quality, and timely delivery.

Featured Application Note

download-pdf
Large Volume Parenteral and Small Volume Parenteral Filtration
Download Now

Featured Application Note

download-pdf
Large Volume Parenteral and Small Volume Parenteral Filtration
Download Now

Featured Application Note

download-pdf
Large Volume Parenteral and Small Volume Parenteral Filtration
Download Now

Quick Links

2D and 3D Bags

We have quality single, double, and triple barrier containment systems to meet your safety, storage, and transportation needs of sterile liquids. We offer 2D barrier bag systems, 3D mulitlayer assembly bags, and Aramus™ assembly systems for cold temperature applications.
Tube Sets and Manifolds

With decades of experience, we can fabricate unique tube sets and manifolds to your exacting specifications. We have solutions for secure fluid transfer, aseptic filling, sterile processing or storage, bioreactor filtration and support, and so much more.