Monitoring Industry Contamination Down to Single Particle Level Using Next-Generation Resistive Pulse Sensing and Fluoropolymer Bags

APPLICATION NOTE

Oligonucleotides are becoming a critical material in the field of life sciences due to their value in creating research tools, vitro diagnostic tests, new nucleic acid-based therapies, mRNA vaccines, and specialized medicines including in vivo gene editing as well as cell and gene therapies. Because oligonucleotide handling can be complex, traditional container approaches may underperform and create significant issues:

• DNA often binds to commercially available polypropylene tubes.
• Oligonucleotides can be lost due to non-specific adsorption onto container walls
• Low-absorption polypropylene vessels and tubes may be cost-prohibitive for high-volume manufacturing