Pharmsteri™ II GHC PES Liquid Capsule Filter

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Delivers superior throughput for broad challenging feed streams while minimize product loss in sterile filtration

Dual layer and highly asymmetric PES membrane minimize pressure build-up while processing large volume fluids
Structure design helps minimize dead zone which can cause loss of high value products
Broad chemical compatibility, pH 1~14, allows use in a range of chemistries including acids and bases
Sterilizing grade meets Bacterial Challenge Test (ASTM F838) which ensures that microorganisms, such as bacteria, are removed from the fluid stream while not adversely affecting product
Gamma capability ensures that integrators can connect these filters into any customer-specific, single-use assembly and provide it as a sterile, final assembled product
Product has been rigorously validated to product specification and industry standards with comprehensive documentation to support compliance

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Size

Inlet and Outlet Connection

Packaging Configuration

Capsule Type

Retention Rating

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Notes:
1. TS/HS/TH code for 3”/5”/10”, FS/BS/FB code for mini/1”, SH code for 50mm disc
2. 5”/10” as 1 ea/box, 3” as 2 ea/box, mini/1” as 4 ea/box, 50mm disc as 3 ea/box
3. Mini/1” under development, sample available for evaluation

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Applications Pharmsteri™ II GHC PES Liquid Capsule Filter Applications

Bioburden or sterile filtration for various process fluids
Cell culture media and additives
Process intermediates in mAb, vaccines, etc.
Column or downstream unit protection
High concentration buffers
Bulk drug substances
Protein solutions or formulations
Other high fouling fluids

Specifications

Drawings

Size - Connections	Total Length - A	Body Diameter - B	Min Width - C	Max Width - D
3-inch TC-TC	154.5 mm (6.08”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
3-inch TC-HB	156.7 mm (6.17”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
3-inch HB-HB	159.7 mm (6.29”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
5-inch TC-TC	213.2 mm (8.39”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
5-inch TC-HB	216.5 mm (8.52”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
5-inch HB-HB	219.5 mm (8.96”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
10-inch TC-TC	335.5 mm (13.21”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
10-inch TC-HB	339.0 mm (13.35”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)
10-inch HB-HB	342.0 mm (13.46”)	96.0 mm (3.78”)	107.0 mm (4.21”)	153.0 mm (6.02”)

Performance Data

Product Specifications

		50mm Disc	3"/5"/10" In-Line Capsules
Materials	Media	Polyethersulfone	Polyethersulfone
	Support	Polypropylene	Polypropylene
	Core, cage, end caps	Polypropylene	Polypropylene
	O-ring	Silicone	Silicone
Sealing technology		Mechanical sealing with O-ring	Thermal bonding without adhesives
Pore size		0.45+0.22 µm 0.65+0.22 µm	0.45+0.22 µm 0.65+0.22 µm
Filtration area		17.3 cm²	3"	0.16 m²
			5"	0.30 m²
			10"	0.60m²
Integrity	Bubble point		≥3.65 bar (53 psi) air with water
	Water Diffusion		3"	≤ 6.8 mL/min @ 40psi @ 25°C (77°F)
			5"	≤ 11.5 mL/min @ 40psi @ 25°C (77°F)
			10"	≤ 21.5 mL/min @ 40psi @ 25°C (77°F)
Maximum operating conditions	Maximum operating pressure	80 psi (5.5 bar) @ 25°C (77°F)	80 psi (5.5 bar) @ 25°C (77°F)
		40 psi (2.8 bar) @ 60°C (140°F)	40 psi (2.8 bar) @ 60°C (140°F)
	Maximum differential pressure	Forward 60 psi (4.1 bar) @ 25°C (77°F)	Forward 60 psi (4.1 bar) @ 25°C (77°F)
		Forward 30 psi (2.1 bar) @ 60°C (140°F)	Forward 30 psi (2.1 bar) @ 60° C (140° F)
		Reverse 10 psi (0.7 bar) @ 25°C (77°F)	Reverse 10 psi (0.7 bar) @ 25°C (77°F)
Bacteria Retention		Sterilizing grade membrane	>10⁷ CFU/cm² B. diminuta per the ASTM F838.
Multiple sterilization Cycles	2 cycles of autoclave, 30 min at 130°C (266°F)
Gamma stability	Gamma irradiation stable up to 45 kGy
Endotoxin releasing*	<0.25 EU/mL as determined by the LAL test, meeting the requirements of USP <85>
Particulates*	Particulate matter release meets the requirement of USP <788>
Non-fiber releasing	Manufactured with non-fiber release materials and tested according to 21 CFR 210.3 (b) (6)
TOC*	<0.5 mg/L post gamma and after a water flush, meeting the requirements of USP <643>
Conductivity*	≤1.3 μS/cm post gamma and after water flush, meeting the requirements of USP <645>
Material toxicity*	All components meet the requirements of the USP <87>, Biological Reactivity Test and the USP <88> Reactivity Test for Class VI Plastics
Animal free	Raw materials used to manufacture this product are not animal derived, meeting the EU directive for animal free CPMP EMA/410/01 and 21 CFR parts 189.5
Extractables*	Tested according to BioPhorum Operations Group (BPOG) guideline. Report is available upon request.
Quality	100% integrity tested, manufactured in accordance with ISO 9001 and ISO 13485 certified quality management system
*Test post-gamma irradiation. Refer to our validation guide for details.

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Reference Materials Product Documentation

Published Feb 27, 2025 Data Sheet Pharmsteri™ II GHC PES Liquid Capsule Filter

565.6 kB

Published Feb 27, 2025 Data Sheet Pharmsteri™ II GHC PES Liquid Capsule Filter - A4

565.6 kB

Part Numbers

Pharmsteri™ II GHC PES Liquid Capsule Filter Part Numbers

Part Number	Size	Inlet and Outlet Connection	Packaging Configuration	Capsule Type	Retention Rating
PSTGSSD042BS01-4	1" capsule	1/4” hose barb	4 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042BS0M-4	Mini	1/4” hose barb	4 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042FB01-4	1" capsule	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042FB0M-4	Mini	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042FS01-4	1" capsule	3/4” TC inlet/outlet	4 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042FS0M-4	Mini	3/4” TC inlet/outlet	4 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042HS03-2	3" capsule	1/2" hose barb	2 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042HS05-1	5" capsule	1/2" hose barb	1 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042HS10-1	10" capsule	1/2" hose barb	1 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042SH00-3	50 mm disc	1/4” hose barb	3 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042TH03-2	3" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	2 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042TH05-1	5" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042TH10-1	10" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042TS03-2	3" capsule	1.5" sanitary TC	2 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042TS05-1	5" capsule	1.5" sanitary TC	1 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD042TS10-1	10" capsule	1.5" sanitary TC	1 ea/box	Gamma Sterilized	0.45 + 0.22 µm
PSTGSSD062BS01-4	1" capsule	1/4” hose barb	4 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062BS0M-4	Mini	1/4” hose barb	4 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062FB01-4	1" capsule	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062FB0M-4	Mini	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062FS01-4	1" capsule	3/4” TC inlet/outlet	4 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062FS0M-4	Mini	3/4” TC inlet/outlet	4 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062HS03-2	3" capsule	1/2" hose barb	2 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062HS05-1	5" capsule	1/2" hose barb	1 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062HS10-1	10" capsule	1/2" hose barb	1 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062SH00-3	50 mm disc	1/4” hose barb	3 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062TH03-2	3" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	2 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062TH05-1	5" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062TH10-1	10" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062TS03-2	3" capsule	1.5" sanitary TC	2 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062TS05-1	5" capsule	1.5" sanitary TC	1 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTGSSD062TS10-1	10" capsule	1.5" sanitary TC	1 ea/box	Gamma Sterilized	0.65 + 0.22 µm
PSTSUSD042BS01-4	1" capsule	1/4” hose barb	4 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042BS0M-4	Mini	1/4” hose barb	4 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042FB01-4	1" capsule	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042FB0M-4	Mini	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042FS01-4	1" capsule	3/4” TC inlet/outlet	4 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042FS0M-4	Mini	3/4” TC inlet/outlet	4 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042HS03-2	3" capsule	1/2" hose barb	2 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042HS05-1	5" capsule	1/2" hose barb	1 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042HS10-1	10" capsule	1/2" hose barb	1 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042SH00-3	50 mm disc	1/4” hose barb	3 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042TH03-2	3" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	2 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042TH05-1	5" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042TH10-1	10" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042TS03-2	3" capsule	1.5" sanitary TC	2 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042TS05-1	5" capsule	1.5" sanitary TC	1 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD042TS10-1	10" capsule	1.5" sanitary TC	1 ea/box	Single Use	0.45 + 0.22 µm
PSTSUSD062BS01-4	1" capsule	1/4” hose barb	4 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062BS0M-4	Mini	1/4” hose barb	4 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062FB0M-4	Mini	3/4” TC inlet, 1/4" hose barb outlet	4 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062FS01-4	1" capsule	3/4” TC inlet/outlet	4 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062FS0M-4	Mini	3/4” TC inlet/outlet	4 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062HS03-2	3" capsule	1/2" hose barb	2 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062HS05-1	5" capsule	1/2" hose barb	1 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062HS10-1	10" capsule	1/2" hose barb	1 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062SH00-3	50 mm disc	1/4” hose barb	3 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062TH03-2	3" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	2 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062TH05-1	5" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062TH10-1	10" capsule	1.5" sanitary TC inlet and 1/2" hose barb outlet	1 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062TS03-2	3" capsule	1.5" sanitary TC	2 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062TS05-1	5" capsule	1.5" sanitary TC	1 ea/box	Single Use	0.65 + 0.22 µm
PSTSUSD062TS10-1	10" capsule	1.5" sanitary TC	1 ea/box	Single Use	0.65 + 0.22 µm