AccuSizer® SPOS Systems

A comprehensive portfolio of high accuracy and resolution liquid particle counters that determine particle size and concentration of your suspensions.

Uses single particle optical sizing (SPOS) technology to provide extended dynamic size and concentration ranges
Can be used as a liquid particle counter for contamination applications or as sophisticated particle size analyzer
Highest sensitivity technology available to determine tails of distribution such as large particle counts (LPC) in CMP slurries, protein aggregates, or tails of emulsions (PFAT5)
Fast, multi-channel pulse height analyzers that can report results in up to 1024 size bins
Several fluidics configurations are available to deliver the sample to the sensor directly or with auto dilution to avoid coincidence errors
Reference our Particle Characterization Applications page for additional information

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Applications AccuSizer® SPOS Systems Applications

AccuSizer SPOS Systems are ideal for measuring particle size and concentration in:

Specifications

System Features

All systems consist of a sensor, pulse height analyzer (counter), and fluidics to transport the sample through the sensor. Particles flowing through the sensor scatter and obscure the incident laser beam. This light interaction creates pulses that are proportional to the particle size. The counter converts these pulses to particle size.

Sensors	LE400	Collimated beam, scatter + extinction, 0.5-400 μm
	FX	Focused beam, extinction 0.7-20 μm at high concentration
	FX-Nano	Focused beam, scatter 0.15-10+ μm at high concentration
Counter	The counter provides high resolution results in up to 1024 size channels
Fluidics	The sample can be transported through the sensor either without dilution or with single and two stage autodilution samplers

High Resolution Particle Counters

AccuSizer SIS System

The most advanced liquid particle counter for USP <787>, <788>, and <789> testing
Syringe pump pulls accurate and precise sample volumes as low as 150 µL
Automated analysis using autosampler and microplate reader available
Two sensor LE400 plus FX-Nano system counts and sizes down to 150 nm

AccuSizer AD System

The most popular for general particle size analysis applications
Performs exponential autodilution while providing accurate concentration information

AccuSizer APS System

Uses a unique, two-stage fluidics system that measures particle size and count in high concentration suspensions
Ideal for high concentration ink samples and for USP <729> testing of lipid injectable emulsions

AccuSizer FX-Nano AD System

Uses LE400 plus FX-Nano sensors with AD-style exponential autodilution down to 150 nm
Can analyze high concentration samples up to 10⁶ particles/mL
Ideal for filter testing and high concentration protein samples

Technical Assistance

To lessen your production downtime, we offer Expedited Instrumentation Technical Assistance.

Successfully Opted for software Updates

Reference Materials Product Documentation

Published Aug 14, 2020 Data Sheet AccuSizer ® A7000 SIS Liquid Particle Counter/ParticleSize Analyzer

277.6 kB

Published Aug 1, 2020 Data Sheet AccuSizer ® A2000 USP Liquid Particle Counter

292.1 kB

Published Apr 29, 2019 Data Sheet AccuSizer® A2000 MPA Microplate Particle Analyzer

373.1 kB

Published May 6, 2019 Data Sheet AccuSizer® A2000 Oil Contamination Monitor

550.3 kB

Published Aug 12, 2019 Data Sheet AccuSizer ® A2000 CMS Automated Liquid Particle Counter for Hydraulic Fluids and Oils

418.9 kB

Published Jul 23, 2019 Data Sheet AccuSizer ® A9000 FX NANO SIS and AD Particle Count/Size Analyzer

558.5 kB

Published Aug 1, 2022 Data Sheet AccuSizer ® Sensors

570.5 kB

Published May 9, 2019 Data Sheet AccuSizer ® A7000 DI Direct Inject Particle Count/Size Analyzer

988.3 kB

Published Jul 26, 2019 Data Sheet AccuSizer® Autosampler

400.5 kB

Published Feb 27, 2020 Data Sheet Why Buy an AccuSizer® SPOS System?

597.4 kB

Published Dec 1, 2023 Brochure AccuSizer ® A7000 Single Particle Optical Sizing

1.4 MB

Published Jan 1, 2022 Brochure Nicomp® N3000 & AccuSizer ® A7000

603.1 kB

Published May 1, 2024 Brochure Synergies to Improve CMP Yield

2.5 MB

Published Sep 1, 2023 Application Note Importance of Particle Size in Powders Used for Additive Manufacturing

1.8 MB

Published Mar 1, 2021 Application Note Monitoring Particulate Contamination in Medical Devices

760.0 kB

Published Sep 1, 2024 Application Note USP <788> Particulate Matter in Injections

566.7 kB

Published Aug 1, 2020 Application Note USP <789> Particulate Matter in Ophthalmic Solutions

672.9 kB

Published May 15, 2020 Application Note Laboratory AccuSizer® Systems for CMP Slurries

2.0 MB

Published Jan 1, 2022 Application Note Mean Particle Size and Zeta Potential Analysis of CMP Slurries

1.4 MB

Published Dec 2, 2019 Application Note CMP Slurries

359.0 kB

Published Jan 6, 2020 Application Note Droplet Size Analysis of Mayonnaise

936.9 kB

Published Dec 16, 2019 Application Note Subvisible Particulate Matter Testing

1.0 MB

Published Dec 2, 2019 Application Note Techniques to Measure Size of CMP Slurries

758.0 kB

Published Dec 1, 2019 Application Note Filter Testing

584.1 kB

Published Nov 20, 2019 Application Note Effect of Silicone Oil Droplets in Pre-Filled Syringes

642.4 kB

Published Oct 2, 2019 Application Note Particle Size Analysis of Active Pharmaceutical Ingredients (APIs)

1.1 MB

Published Oct 4, 2019 Application Note ISO 4406 Testing: ContaminationParticles in Oil

592.8 kB

Published Oct 4, 2019 Application Note Soft Drink Emulsions

551.6 kB

Published Sep 13, 2019 Application Note Emulsion Stability

1.2 MB

Published Dec 1, 2021 Application Note USP <729> Globule Size Distribution in Lipid Injectable Emulsions

510.5 kB

Published Sep 12, 2019 Application Note Protein Aggregation

1.6 MB

Published Sep 12, 2019 Application Note Liposomes

856.9 kB

Published Jan 1, 2018 Application Note Aramus™ Single-Use Bag Particle Testing

561.2 kB

Published Mar 1, 2022 Application Note Particle Size of Inkjet Inks

922.4 kB

Published Aug 14, 2019 Application Note Detecting Tails in CMP Slurries

353.1 kB

Published Jul 29, 2019 Application Note Microbubbles

290.8 kB

Published Jul 25, 2019 Application Note CMP Slurry Filter Testing

607.7 kB

Published Jul 25, 2019 Application Note USP <787> Testing Therapeutic Protein Injections

436.3 kB

Published Jul 30, 2019 Application Note Protein Formulation Screening and USP <787> Testing

1.3 MB

Published Oct 1, 2021 Application Note Particulate Contamination Levels in Single-Use Systems

756.0 kB

Published Feb 1, 2022 Application Note Cannabis Emulsion Droplet Size Analysis

1.2 MB

Published Jan 1, 2024 Application Note Lab and Online Particle Size Analysis of Silicas

1.1 MB

Published Jul 1, 2024 Technical Note Installing the MCPA Counter USB Hub

165.5 kB

Published Sep 1, 2023 Technical Note AccuSizer® 3.1.4.0 Software Release Notification

782.5 kB

Published Jan 1, 2022 Technical Note AccuSizer® SPOS System and Nicomp® DLS System

378.3 kB

Published Apr 30, 2020 Technical Note AccuSizer® System Version 3.0 Software Testing

1.6 MB

Published Apr 17, 2020 Technical Note Autodilution AccuSizer® SPOS System

142.9 kB

Published Dec 13, 2019 Technical Note Cleaning Procedure for AccuSizer A2000

75.6 kB

Published Oct 1, 2019 Technical Note Particle Count Standards

219.1 kB

Published Sep 12, 2019 Technical Note Cleaning Methods AccuSizer ® FX Nano

80.0 kB

Published Sep 12, 2019 Technical Note How Many Particles to Measure

172.9 kB

Published Aug 20, 2019 Technical Note Low Volume Particle Size and Count Analysis

108.8 kB

Published Aug 12, 2019 Technical Note AccuSizer ® Data Interpretation

844.5 kB

Published Aug 7, 2019 Technical Note SPOS vs. Laser Diffraction

1.1 MB

Published Sep 1, 2022 Flyer Oligonucleotide Manufacturing

176.7 kB

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